What is Avmacol® Extra Strength?

Avmacol® Extra Strength is a patented, sulforaphane-producing supplement that works in combination with Maitake mushroom extract (containing beta-glucans) to support your body's natural detoxification process better than sulforaphane alone.1 Avmacol® Extra Strength provides glucoraphanin, also known as sulforaphane glucosinolate, and active myrosinase enzyme, which are the essential ingredients needed for sulforaphane production. Without active myrosinase enzyme, one may not be able to reap sulforaphane’s many health-promoting benefits.

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What are the Ingredients?

Avmacol® Extra Strength contains the essential ingredients necessary for sulforaphane production in the body, broccoli seed extract (Glucoraphanin) and Myrosimax® (Active Myrosinase Enzyme). Avmacol® Extra Strength also contains Maitake mushroom extract for added immune and detoxification support.

Supplement Facts

Directions for Use: Take one (1) tablet per day with a meal. If you have a condition that requires medical attention always consult your physician before taking any dietary supplement.

OTHER INGREDIENTS: MICROCRYSTALLINE CELLULOSE, MALTODEXTRIN, HYDROXYPROPYL CELLULOSE, STARCH

CONTAINS < 2% OF: CROSCARMELLOSE SODIUM, SILICON DIOXIDE, AND MAGNESIUM STEARATE

Serving Size 1 Tablet
Servings Per Container 30
Amount Per Serving
% Daily Value
Total Carbohydrates
less than 1 g
Vitamin C from Asorbic Acid
25 mg
28%
Proprietary Sulforaphane Glucosinolate (Glucoraphanin) & Myrosinase Blend
25 mg
28%

How Maitake Mushroom Extract Works in Combination with Sulforaphane

The Maitake mushroom extract (containing beta-glucans) works in combination with sulforaphane to support your body’s natural detoxification process better than sulforaphane alone.1 In addition, the Maitake mushroom extract found in Avmacol® Extra Strength provides the added bonus of immune support by promoting neutrophil function and natural killer cell activity.

The Science Behind Avmacol®
Extra Strength

The combination of sulforaphane and Maitake extract supports the movement (or translocation) from the cytoplasm to the nucleus of NRF2 and increases the levels of certain Phase 2 enzymes. Below are images of a technique called immunofluorescence which illustrate how much protein is being produced in the cell and the location of that protein.

Translocation of NRF2 into the Nucleus Following Exposure to Sulforaphane and Maitake Mushroom Extract

control
sulforaphane + maitake

In control cells (left panel), the green staining indicates that NRF2 remains largely in the cytoplasm (arrows) without much protein located in the nucleus, which is counter-stained in blue. When cells are exposed to sulforaphane and Maitake (right panel), NRF2 moves to the nucleus (arrows) where it can bind to DNA to turn on expression of certain Phase 2 enzymes.

Sulforaphane and Maitake Extract Boosts Select Phase 2 Enzyme Production Including NQO1 and HO-1

NQO1 Protein Expression in THLE2 Liver Cells

control
sulforaphane + maitake

In control cells (left panel) NQO1 protein expression is indicated by the green staining. When cells are exposed to sulforaphane and Maitake (right panel), the level of NQO1 staining, representing the amount of protein, is increased.

HO-1 Protein Expression in THLE2 Liver Cells

control
sulforaphane + maitake

In control cells (left panel) HO-1 protein expression is indicated by the green staining. When cells are exposed to sulforaphane and Maitake (right panel), the level of HO-1 staining, representing the amount of protein, is increased.

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1 In a laboratory study, treatment of RAW 264.7 cells with the combination of Maitake mushroom extract and sulforaphane resulted in greater induction of the expression of Phase 2 enzyme NQO1 than either individual component alone.